Famous in particular for its massive dome, it is considered the epitome of Byzantine architecture and is said to have "changed the history of architecture." It remained the world's largest cathedral for nearly a thousand years thereafter, until Seville Cathedral was completed in 1520. The current building was originally constructed as a church between 532 and 537 on the orders of the Byzantine Emperor Justinian and was the third Church of the Holy Wisdom to occupy the site, the previous two having both been destroyed by rioters. It was designed by the Greek scientists Isidore of Miletus, a physicist, and Anthemius of Tralles, a mathematician.