The church was seriously damaged in 1940 resulted in total detruction of the church's interior but it was reconstructed in the 1950's.
By the time the Great Fire of 1666 left the church in ruins, a succession of churches had existed on the site for about a millennium, and the area had already assumed its unique role in the emergence of English printing. It took nine years for St Bride's to re-appear from the ashes under the inspired direction of Christopher Wren, but for the next two-and-a-half centuries it was in the shadow of the church's unmistakeable wedding-cake spire that the rise of the British newspaper industry into the immensely-powerful Fourth Estate took place.

Then, in 1940, St Bride's fell victim once again to flames as German incendiary bombs reduced Wren's architectural jewel to a roofless shell. This time 17 years elapsed before rebuilding was completed, although a series of important excavations in 1953 amid the skeletal ruins, led by the medieval archaeologist Professor W. F. Grimes, came up with extraordinary results, uncovering the foundations of all six previous churches on the site.